USP11 regulates PML stability to control Notch-induced malignancy in brain tumours
The promyelocytic leukaemia (PML) protein controls multiple tumour suppressive functions
and is downregulated in diverse types of human cancers through incompletely characterized …
and is downregulated in diverse types of human cancers through incompletely characterized …
Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration
G Sorrentino, A Comel, F Mantovani, G Del Sal - Mitochondrion, 2014 - Elsevier
Mitochondria are sensitive and efficient organelles that regulate essential biological
processes including: energy metabolism, decoding and transduction of intracellular signals …
processes including: energy metabolism, decoding and transduction of intracellular signals …
SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling
YC Lin, LT Lu, HY Chen, X Duan, X Lin, XH Feng… - Cancer research, 2014 - AACR
The tumor-suppressor protein promyelocytic leukemia (PML) is aberrantly degraded in
multiple types of human cancers through mechanisms that are incompletely understood …
multiple types of human cancers through mechanisms that are incompletely understood …
Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death
The promyelocytic leukemia protein (PML) is a tumor suppressor that is expressed at a low
level in various cancers. Although post-translational modifications including SUMOylation …
level in various cancers. Although post-translational modifications including SUMOylation …
PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2
Promyelocytic leukemia protein (PML) is emerging as an important tumor suppressor. Its
expression is lost during the progression of several types of cancer, including lung cancer …
expression is lost during the progression of several types of cancer, including lung cancer …
[HTML][HTML] Expression of E6AP and PML predicts for prostate cancer progression and cancer-specific death
Background The promyelocytic leukemia (PML) tumor suppressor plays an important role in
the response to a variety of cellular stressors and its expression is downregulated or lost in a …
the response to a variety of cellular stressors and its expression is downregulated or lost in a …
[HTML][HTML] PML tumour suppression and beyond: therapeutic implications
Recognition of the tumour suppressive capacity of the Promyelocytic Leukemia protein
(PML) has emerged beyond its identification through APL, to a broad spectrum of tumors …
(PML) has emerged beyond its identification through APL, to a broad spectrum of tumors …
High expression of AT-rich interactive domain 3A (ARID3A) is associated with good prognosis in colorectal carcinoma
M Song, H Kim, WK Kim, SP Hong, C Lee… - Annals of surgical …, 2014 - Springer
Background AT-rich interactive domain 3A (ARID3A) is a member of the ARID family of DNA-
binding proteins. Previous reports have shown that ARID3A controls cell growth in a p53 …
binding proteins. Previous reports have shown that ARID3A controls cell growth in a p53 …
The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies
KL Rice, H de Thé - Journal of internal medicine, 2014 - Wiley Online Library
The recent finding that almost all patients with acute promyelocytic leukaemia (APL) may be
cured using a combination of retinoic acid (RA) and arsenic trioxide (A s2 O 3)(N Engl J …
cured using a combination of retinoic acid (RA) and arsenic trioxide (A s2 O 3)(N Engl J …