Genetic labeling of neurons with a specific response feature is an emerging technology for
precise dissection of brain circuits that are functionally heterogeneous at the single-cell …

The organism's ability to adapt to the changing sensory environment is due in part to the
ability of the nervous system to change with experience. Input and synapse specific Hebbian …

The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal,
and thalamic structures harboring spatially modulated neurons. The RSC contains head …

Learning to recognize and predict temporal sequences is fundamental to sensory perception
and is impaired in several neuropsychiatric disorders, but little is known about where and …

Recent advances in genetically encoded fluorescent sensors enable the monitoring of
cellular events from genetically defined groups of neurons in vivo. In this protocol, we …

The dynamic processes of formatting long-term memory traces in the cortex are poorly
understood. The investigation of these processes requires measurements of task-evoked …

Experience refines synaptic connectivity through neural activity-dependent regulation of
transcription factors. Although activity-dependent regulation of transcription factors has been …

The mesofrontal dopaminergic circuit, which connects the midbrain motivation center to the
cortical executive center, is engaged in control of motivated behaviors. In addition …

The brain encodes information about past experience in specific populations of neurons that
communicate with one another by firing action potentials. Studies of experience-dependent …

Intraneuronal neurofibrillary tangles (NFTs)–a characteristic pathological feature of
Alzheimer's and several other neurodegenerative diseases–are considered a major target …