The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in
regulating skeletal muscle size. Several other ligands, including GDF11 and the activins …

In 1997, McPherron et al. created the so-called Mighty Mouse: owing to the knock-out of a
new member of the TGF-β superfamily of peptides, this mouse line was extremely …

Abstract Background The Chinese medicine formulation ISF-1 (also known as Bu-Yang-
Huan-Wu-Tang) for post-stroke rehabilitation could increase the expression of growth …

It has been suggested, mainly by in vitro findings, that cardiovascular tissue in the
spontaneously hypertensive rat (SHR) should be more prone to proliferate/hypertrophy than …

Background/Aims: Overexpression of Gasp-1, an inhibitor of myostatin, leads to a
hypermuscular phenotype due to hypertrophy rather than hyperplasia in mice. However to …

Attenuating myostatin enhances striated muscle growth, reduces adiposity, and improves
cardiac contractility. To determine whether myostatin influences tissue potency in a manner …

Targeting of pre-mRNA by short splice-switching oligonucleotides (SSOs) is increasingly
being used as a therapeutic modality, one rationale being to disrupt splicing so as to remove …

Mucopolysaccharidosis II (MPS II), also known as Hunter syndrome, is a rare X-linked
recessive lysosomal storage disorder with an incidence of 1 in 100 000 to 160 000 live …

Rare neuromuscular diseases encompass many diverse and debilitating musculoskeletal
disorders, ranging from ultra-orphan conditions that affect only a few families, to the so …

O objetivo deste trabalho foi avaliar a carga máxima suportada pelo músculo gastrocnêmio
de ratas após intervenção com Cystoseira canariensis, associado ou não à natação. Foram …