The emerging roles of TCF4 in disease and development
Genome-wide association studies have identified common variants in transcription factor 4
(TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and …
(TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and …
Structural variation and genome complexity: is dispensable really dispensable?
Highlights•Structural variants are the major components of dispensable genome.•Structural
variants might have important functional consequences.•Next generation sequencing is a …
variants might have important functional consequences.•Next generation sequencing is a …
MBASED: allele-specific expression detection in cancer tissues and cell lines
O Mayba, HN Gilbert, J Liu, PM Haverty… - Genome biology, 2014 - Springer
Allele-specific gene expression, ASE, is an important aspect of gene regulation. We
developed a novel method MBASED, meta-analysis based allele-specific expression …
developed a novel method MBASED, meta-analysis based allele-specific expression …
Using Galaxy-P to leverage RNA-Seq for the discovery of novel protein variations
GM Sheynkman, JE Johnson, PD Jagtap… - BMC genomics, 2014 - Springer
Background Current practice in mass spectrometry (MS)-based proteomics is to identify
peptides by comparison of experimental mass spectra with theoretical mass spectra derived …
peptides by comparison of experimental mass spectra with theoretical mass spectra derived …
[PDF][PDF] A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell
JR Kulzer, ML Stitzel, MA Morken, JR Huyghe… - The American Journal of …, 2014 - cell.com
Genome-wide association studies (GWASs) have identified more than 70 loci associated
with type 2 diabetes (T2D), but for most, the underlying causal variants, associated genes …
with type 2 diabetes (T2D), but for most, the underlying causal variants, associated genes …
[HTML][HTML] Different yet similar: evolution of imprinting in flowering plants and mammals
ND Pires, U Grossniklaus - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Genomic imprinting refers to a form of epigenetic gene regulation whereby alleles are
differentially expressed in a parent-of-origin-dependent manner. Imprinting evolved …
differentially expressed in a parent-of-origin-dependent manner. Imprinting evolved …
Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans
D Muzzey, G Sherlock, JS Weissman - Genome research, 2014 - genome.cshlp.org
Though sequence differences between alleles are often limited to a few polymorphisms,
these differences can cause large and widespread allelic variation at the expression level …
these differences can cause large and widespread allelic variation at the expression level …
Functional interpretation of non‐coding sequence variation: concepts and challenges
Understanding the functional mechanisms underlying genetic signals associated with
complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is …
complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is …
Comprehensive analysis of the whole transcriptomes from two different pig breeds using RNA‐Seq method
Next‐generation sequencing RNA‐Seq technology is a powerful tool that creates new
possibilities for whole‐transcriptome analysis. In our study, the RNA‐Seq method was …
possibilities for whole‐transcriptome analysis. In our study, the RNA‐Seq method was …
Mutated tumor alleles are expressed according to their DNA frequency
The transcription of tumor mutations from DNA into RNA has implications for biology,
epigenetics and clinical practice. It is not clear if mutations are in general transcribed and, if …
epigenetics and clinical practice. It is not clear if mutations are in general transcribed and, if …