Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Chromatin dynamics play an essential role in regulating the accessibility of genomic DNA for
a variety of nuclear processes, including gene transcription and DNA repair. The …

Summary The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for
embryonic development and pluripotent stem cell differentiation. In this study, we …

Brain-derived neurotrophic factor (BDNF) is a key mediator of the activity-dependent
processes in the brain that have a major impact on neuronal development and plasticity …

Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor
complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and …

Methylation of CpG dinucleotides is a reversible modification of DNA that is highly prevalent
throughout mammalian genomes. Recent advances generated genomic DNA methylation …

Many tumor suppressor genes (TSGs) are silenced through synergistic layers of epigenetic
regulation including abnormal DNA hypermethylation of promoter CpG islands, repressive …

Alternative RNA splicing (AS) regulates proteome diversity, including isoform-specific
expression of several pluripotency genes. Here, we integrated global gene expression and …

In pluripotent stem cells, the interplay between signaling cues, epigenetic regulators and
transcription factors orchestrates developmental potency. Flexibility in gene expression …

Cytosine methylation is a well recognized epigenetic mark. Here, the methylation status of a
salinity-tolerant wheat cultivar (cv. SR3, derived from a somatic hybridization event) and its …