Identifying miRNAs, targets and functions

B Liu, J Li, MJ Cairns - Briefings in bioinformatics, 2014 - academic.oup.com
Abstract microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …

[HTML][HTML] Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease

B Hrdlickova, RC de Almeida, Z Borek… - Biochimica et Biophysica …, 2014 - Elsevier
It has been found that the majority of disease-associated genetic variants identified by
genome-wide association studies are located outside of protein-coding regions, where they …

HMDD v2. 0: a database for experimentally supported human microRNA and disease associations

Y Li, C Qiu, J Tu, B Geng, J Yang, T Jiang… - Nucleic acids …, 2014 - academic.oup.com
Abstract The Human microRNA Disease Database (HMDD; available via the Web site at
http://cmbi. bjmu. edu. cn/hmdd and http://202.38. 126.151/hmdd/tools/hmdd2. html) is a …

The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations

Y Ru, KJ Kechris, B Tabakoff, P Hoffman… - Nucleic acids …, 2014 - academic.oup.com
Abstract microRNAs (miRNAs) regulate expression by promoting degradation or repressing
translation of target transcripts. miRNA target sites have been catalogued in databases …

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

SD Hsu, YT Tseng, S Shrestha, YL Lin… - Nucleic acids …, 2014 - academic.oup.com
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively
regulating gene expression to control many cellular mechanisms. The miRTarBase …

Long noncoding RNA associated-competing endogenous RNAs in gastric cancer

T Xia, QI Liao, X Jiang, Y Shao, B Xiao, Y Xi, J Guo - Scientific reports, 2014 - nature.com
Some long noncoding RNAs (lncRNAs) play important roles in the regulation of gene
expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of …

miRWalk database for miRNA–target interactions

H Dweep, N Gretz, C Sticht - RNA mapping: methods and protocols, 2014 - Springer
Abstract miRWalk (http://mirwalk. uni-hd. de/) is a publicly available comprehensive
resource, hosting the predicted as well as the experimentally validated microRNA (miRNA) …

Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer

A Mittal, D Chitkara, SW Behrman, RI Mahato - Biomaterials, 2014 - Elsevier
Clinical effectiveness of gemcitabine in pancreatic cancer is hindered due to its rapid
plasma metabolism and development of chemo-resistance. We have previously delineated …

The role of RNA structure at 5′ untranslated region in microRNA-mediated gene regulation

W Gu, Y Xu, X Xie, T Wang, JH Ko, T Zhou - Rna, 2014 - rnajournal.cshlp.org
Recent studies have suggested that the secondary structure of the 5′ untranslated region
(5′ UTR) of messenger RNA (mRNA) is important for microRNA (miRNA)-mediated gene …

The new world of RNAs

DB Dogini, VD Pascoal, SH Avansini… - … and molecular biology, 2014 - SciELO Brasil
One of the major developments that resulted from the human genome sequencing projects
was a better understanding of the role of non-coding RNAs (ncRNAs). NcRNAs are divided …