Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects

S Barua, S Mitragotri - Nano today, 2014 - Elsevier
Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Y Li, K Xiao, W Zhu, W Deng, KS Lam - Advanced drug delivery reviews, 2014 - Elsevier
Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for
drug delivery against cancers. SCMs exhibit superior structural stability compared to their …

Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin

M Li, Z Tang, S Lv, W Song, H Hong, X Jing, Y Zhang… - Biomaterials, 2014 - Elsevier
Abstract pH responsive cisplatin prodrug crosslinked polysaccharide-based nanoparticles
were developed from succinic acid decorated dextran (Dex-SA) for active loading and …

Nanotechnology-based intelligent drug design for cancer metastasis treatment

Y Gao, J Xie, H Chen, S Gu, R Zhao, J Shao… - Biotechnology advances, 2014 - Elsevier
Traditional chemotherapy used today at clinics is mainly inherited from the thinking and
designs made four decades ago when the Cancer War was declared. The potency of those …

Polymer nanoparticles for smart drug delivery

D Bennet, S Kim - Application of nanotechnology in drug delivery, 2014 - books.google.com
In the recent decades, polymers are widely used as biomaterials due to their favorable
properties such as good biocompatibility, easy design and preparation, a variety of …

Applications of nanomaterials as vaccine adjuvants

M Zhu, R Wang, G Nie - Human vaccines & immunotherapeutics, 2014 - Taylor & Francis
Vaccine adjuvants are applied to amplify the recipient's specific immune responses against
pathogen infection or malignancy. A new generation of adjuvants is being developed to …

A smart nanoassembly for multistage targeted drug delivery and magnetic resonance imaging

Z Li, K Dong, S Huang, E Ju, Z Liu… - Advanced Functional …, 2014 - Wiley Online Library
Efficient delivery of DNA‐toxin anticancer drugs into nucleus of targeted tumor cells while
simultaneously minimizing the side effects to normal tissue is a major challenge for cancer …

Organic nanoparticles for drug delivery and imaging

S Mitragotri, P Stayton - Mrs Bulletin, 2014 - cambridge.org
Nanotechnology has had a huge impact on the development of therapeutics over the last
couple of decades. To date, a large number of organic nanoparticles have been developed …

Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications

S Wong, MS Shim, YJ Kwon - Journal of Materials Chemistry B, 2014 - pubs.rsc.org
Peptide-based biomaterials have been extensively investigated for biomedical applications
due to their high structural and functional versatility. Particularly, peptides that can respond …

Redox potential ultrasensitive nanoparticle for the targeted delivery of camptothecin to HER2-positive cancer cells

RB KC, V Chandrashekaran, B Cheng… - Molecular …, 2014 - ACS Publications
Ideal “smart” nanoparticles for drug delivery should enhance therapeutic efficacy without
introducing side effects. To achieve that, we developed a drug delivery system (HCN) based …