The mononuclear phagocyte system (MPS) has historically been categorized into
monocytes, dendritic cells and macrophages on the basis of functional and phenotypical …

Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …

Summary Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical
roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs …

The development of an effective vaccine that elicits a strong and durable T cell response
against intracellular pathogens and cancer is a challenge. One strategy to enhance the …

Dendritic cells (DC) represent a heterogeneous population of antigen-presenting cells that
are crucial in initiating and shaping immune responses. Although all DC are capable of …

Multiple subsets of FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent dendritic cells
(DCs) control T-cell tolerance and immunity. In mice, Batf3-dependent CD103+ DCs …

Despite significant effort, the development of effective vaccines inducing strong and durable
T-cell responses against intracellular pathogens and cancer cells has remained a …

Infection with influenza A virus (IAV) is a major cause of worldwide morbidity and mortality.
Recent findings indicate that T cell immunity is key to limiting severity of disease arising from …

The intestine presents a huge surface area to the outside environment, a property that is of
critical importance for its key functions in nutrient digestion, absorption, and waste disposal …

Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a
promising immunological tool for cancer therapy. These stimulate the antitumor response …