Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …

Acetylcholine (ACh) has been the first molecule to be identified as neurotransmitter. The
cholinergic and cholinoceptive areas, both in central and peripheral nervous system, have …

A series of novel tacrine derivatives and tacrine–coumarin heterodimers were designed,
synthesized, and biologically evaluated for their potential inhibitory effect on both …

A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as
dual-binding inhibitors of acetylcholinesterase (AChE). The target compounds 3a–u were …

A new ratiometric fluorescent probe derived from 2-(2-hydroxy-3-methoxyphenyl)
benzothiazole (HMBT) has been developed for selective monitoring of human …

Ellman's assay is the most commonly used method to measure cholinesterase activity. It is
cheap, fast, and reliable, but it has limitations when used for biological samples. The …

A new ratiometric fluorescent probe derived from 4-hydroxy-N-butyl-1, 8-naphthalimide
(HNN) has been developed for selective detection of human carboxylesterase 2 (hCE2). The …

Designing drugs with a specific multi-target profile is a promising approach against
multifactorial illnesses as Alzheimer's disease. In this work, new indazole ethers that …

Background A varying response to cholinesterase inhibitor (ChEI) treatment has been
reported among patients with Alzheimer's disease (AD). Whether the individual-specific …

In the introductory chapter, the critical review about the use of small molecules of natural
origin deals with the consequences of pathophysiological processes of Alzheimer's disease …