Improvements in the control of haemorrhage after trauma have resulted in the survival of
many people who would otherwise have died from the initial loss of blood. However, the …

Introduction: Most preventable trauma deaths are due to uncontrolled hemorrhage. Methods:
In this article, we briefly describe the pathophysiology of the classical triad of death in …

Background The British Paediatric Association, the forerunner of the Royal College of
Paediatrics and Child Health (RCPCH), first published guidance in relation to research …

Growing evidence suggests that plasmin is involved in a number of physiological processes
in addition to its key role in fibrin cleavage. Plasmin inhibition is critical in preventing …

Methods: We performed a prospective randomized controlled trial (1: 1 fashion) on the use
of tranexamic acid versus placebo in 50 patients undergoing TKA (without tourniquet). The …

Background Over the last 10 years, the paradigm of damage control resuscitation (DCR) has
been associated with improved patient outcomes. This study investigates the outcomes of …

Transfusion and resuscitation practices in trauma have undergone a sea change over the
past decade. New understanding of transfusion physiology and experiences in military …

Haemophilia patients with inhibitors require bypassing agents (BPA) like activated
prothrombin complex concentrate (aPCC) and recombinant activated factor VII (rFVIIa) to …

Transfusion in trauma has to be an individual decision for a specific patient, not for a specific
laboratory value. Transfusion management must aim at reducing or even avoiding the use of …

Background: While combat casualty care shares many key concepts with civilian trauma
systems, its unique features mandate certain practices that are distinct from the civilian ones …