n-3 LCPUFA improves cognition: the young, the old and the sick

C Joffre, A Nadjar, M Lebbadi, F Calon… - … Leukotrienes and Essential …, 2014 - Elsevier
Due to the implication of docosahexaenoic acid (DHA) in neurogenesis, synaptogenesis,
neurite outgrowth and to its high incorporation into the brain, this n-3 long chain …

Tau mutants bind tubulin heterodimers with enhanced affinity

S Elbaum-Garfinkle, G Cobb… - Proceedings of the …, 2014 - National Acad Sciences
Tau is a microtubule binding protein that forms pathological aggregates in the brain in
Alzheimer's disease and other tauopathies. Disease etiology is thought to arise from loss of …

In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals

ER Zimmer, A Leuzy, V Bhat, S Gauthier… - Translational …, 2014 - Springer
Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles
(NFTs) is a common feature in a wide range of neurodegenerative diseases known as …

阿尔茨海默病实验动物模型方法及评价

王莹, 刘玉刚, 张丹参 - 神经药理学报, 2014 - cqvip.com
阿尔茨海默病(Alzheimer's disease, AD) 是一种神经退行性疾病, 临床表现为认知功能障碍,
病理学研究发现脑萎缩, 细胞外老年斑(senile plaque, SP) 沉积及细胞内出现神经纤维缠结 …

Integrating the molecular and the population approaches to dementia research to help guide the future development of appropriate therapeutics

S Hunter, C Brayne - Biochemical Pharmacology, 2014 - Elsevier
Dementia research over the last 50 years has expanded enormously and has greater
international interest now than at any time in history. A variety of scientific approaches have …

[PDF][PDF] Prostaglandins, Leukotrienes and Essential Fatty Acids

C Joffre, A Nadjar, M Lebbadi, F Calon… - cognitive …, 2014 - optinutribrain.ulaval.ca
abstract Due to the implication of docosahexaenoic acid (DHA) in neurogenesis,
synaptogenesis, neurite outgrowth and to its high incorporation into the brain, this n-3 long …

Applications of small-animal imaging in neurology and psychiatry

C Casteels, H Zaidi, K Van Laere - Molecular Imaging of Small Animals …, 2014 - Springer
Next to genetical testing and behavioural observations, neuroimaging studies are
increasingly performed on primates and rodents to model a variety of human diseases and …

[PDF][PDF] El papel del ejercicio físico en la inducción de BDNF y sus vías de señalización en el sistema nervioso central. Aplicación neurobiológica en modelos sanos y …

HP Galeano - 2014 - roderic.uv.es
Figura I. 1. La hipótesis neurotrófica para la plasticidad de la transmisión
sináptica................................................................................................................................. 16 Figura I …

Accumulation of Abnormally Processed Tau Protein in Neuronal Cells as a Biomarker for Dementia

J Luna-Muñoz, A Martínez-Maldonado… - …, 2014 - books.google.com
Among neurodegenerative diseases, dementias are an heterogeneous group in terms of
their symptoms and pathological findings. One of the main risk factors for developing …

Luminescent conjugated oligothiophenes as diagnostic tools and potential pharmacophores in Alzheimer´ s disease

S Handrick - 2014 - refubium.fu-berlin.de
LCOs sind neuartige, konformations-sensitive optische Amyloid-Marker, die je nach Struktur
der gebundenen, pathologischen Amyloid-Ablagerungen Fluoreszenzlicht unterschiedlicher …