Targeting antioxidants for cancer therapy

A Glasauer, NS Chandel - Biochemical pharmacology, 2014 - Elsevier
Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

Molecular mechanisms underlying chronic inflammation-associated cancers

Y Wu, S Antony, JL Meitzler, JH Doroshow - Cancer letters, 2014 - Elsevier
Highlights•Redox-related transcription factor upregulation characterizes inflammation-
related cancer.•NADPH oxidase-dependent ROS are associated with inflammation and …

Investigation of angiogenesis and its mechanism using zinc oxide nanoparticle-loaded electrospun tissue engineering scaffolds

R Augustine, EA Dominic, I Reju, B Kaimal… - Rsc Advances, 2014 - pubs.rsc.org
Angiogenesis through tissue engineering scaffolds is an important factor that determines the
success of a tissue engineering endeavor. Zinc oxide (ZnO) nanoparticles are well known …

NADPH oxidases: a perspective on reactive oxygen species production in tumor biology

JL Meitzler, S Antony, Y Wu, A Juhasz… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

[HTML][HTML] Pattern-recognition receptors and gastric cancer

N Castaño-Rodríguez, NO Kaakoush… - Frontiers in …, 2014 - frontiersin.org
Chronic inflammation has been associated with an increased risk of several human
malignancies, a classic example being gastric adenocarcinoma (GC). Development of GC is …

Reactive oxygen species: physiological roles in the regulation of vascular cells

D Vara, G Pula - Current molecular medicine, 2014 - ingentaconnect.com
Reactive oxygen species (ROS) are now appreciated to play several important roles in a
number of biological processes and regulate cell physiology and function. ROS are a …

[HTML][HTML] Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer

N Wang, T Zhan, T Ke, X Huang, D Ke, Q Wang… - British journal of …, 2014 - nature.com
Background: The purpose of this study was to confirm that RRM2 as a novel target of HPVE7
involved in cervical cancer angiogenesis. Methods: Gene expression was analysed by RT …

[PDF][PDF] Free radicals, antioxidants and disease

N Sharma - Biology and Medicine, 2014 - Citeseer
Living cells continually generate free radicals or reactive oxygen species (ROS) through the
respiratory chain during energetic metabolism. ROS can either be harmful or play important …

[HTML][HTML] The role of reactive oxygen species in microvascular remodeling

MC Staiculescu, C Foote, GA Meininger… - International journal of …, 2014 - mdpi.com
The microcirculation is a portion of the vascular circulatory system that consists of resistance
arteries, arterioles, capillaries and venules. It is the place where gases and nutrients are …

Mitochondrial dysfunction in cancer

K Księżakowska-Łakoma, M Żyła… - Menopause Review …, 2014 - termedia.pl
Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial
functions such as generating most of the cellular energy through the oxidative …