Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

The p53 tumor suppressor plays a central role in dictating cell survival and death as a
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …

Tumor suppressor p53 plays a pivotal role in tumor suppression. p53 is the most frequently
mutated gene in cancer. As a transcription factor, p53 mainly exerts its role in tumor …

Background & Aims Cancer cells exhibit the reprogrammed metabolism characterized by
high level of glycolysis even in the presence of oxygen. Aerobic glycolysis, known as the …

Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes
reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The …

Autosomal recessive mutations in the thymidine kinase 2 gene (TK2) cause mitochondrial
DNA depletion, multiple deletions, or both due to loss of TK 2 enzyme activity and ensuing …

Mitochondrial DNA (mtDNA) depletion syndrome (MDS) is characterized by a reduction in
mtDNA copy number and consequent mitochondrial dysfunction in affected tissues. A …

MGME1, also known as Ddk1 or C20orf72, is a mitochondrial exonuclease found to be
involved in the processing of mitochondrial DNA (mtDNA) during replication. Here, we …

Mitochondria are essential organelles within the cell where most of the energy production
occurs by the oxidative phosphorylation system (OXPHOS). Critical components of the …

Synthesis of deoxynucleoside triphosphates (dNTPs) is essential for both DNA replication
and repair and a key step in this process is catalyzed by ribonucleotide reductases (RNRs) …