The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …

We recommend a new term,“primary age-related tauopathy”(PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Background Cigarette smoking has been linked with both increased and decreased risk for
Alzheimer's disease (AD). This is relevant for the US military because the prevalence of …

Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

As the US elderly population continues to expand rapidly, Alzheimer's disease poses a
major and increasing public health challenge, and older African Americans may be …

Importance Assessing the ability of Alzheimer disease neuroimaging markers to predict
short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming …

The spectrum of mixed brain pathologies expands beyond accompanying vascular
pathology in brains with Alzheimer's disease-related pathology. Co-occurrence of …