The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - ASPET
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

[HTML][HTML] Neuroinflammation after intracerebral hemorrhage

E Mracsko, R Veltkamp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …

Metastasis review: from bench to bedside

AM Alizadeh, S Shiri, S Farsinejad - Tumor biology, 2014 - Springer
Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Mathematical modelling of cancer invasion: implications of cell adhesion variability for tumour infiltrative growth patterns

P Domschke, D Trucu, A Gerisch… - Journal of theoretical …, 2014 - Elsevier
Cancer invasion, recognised as one of the hallmarks of cancer, is a complex, multiscale
phenomenon involving many inter-related genetic, biochemical, cellular and tissue …

Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy

M Ammendola, C Leporini, I Marech… - BioMed research …, 2014 - Wiley Online Library
Angiogenesis is a complex process finely regulated by the balance between angiogenesis
stimulators and inhibitors. As a result of proangiogenic factors overexpression, it plays a …

Synergy effects of copper and silicon ions on stimulation of vascularization by copper-doped calcium silicate

N Kong, K Lin, H Li, J Chang - Journal of Materials Chemistry B, 2014 - pubs.rsc.org
Copper (Cu) has been reported to be able to stimulate vascularization/angiogenesis, which
is critical for regeneration of vascularized tissue in tissue engineering. Silicate bioceramics …

A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach

M Traylor, KM Mäkelä, LL Kilarski, EG Holliday… - PLoS …, 2014 - journals.plos.org
Genome-wide association studies (GWAS) have begun to identify the common genetic
component to ischaemic stroke (IS). However, IS has considerable phenotypic …

From plasminogen to plasmin: role of plasminogen receptors in human cancer

M Didiasova, L Wujak, M Wygrecka… - International Journal of …, 2014 - mdpi.com
Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of
wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer …

Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior

PF Slivka, CL Dearth, TJ Keane, FW Meng… - Biomaterials …, 2014 - pubs.rsc.org
Extracellular matrix (ECM) derived from mammalian tissues has been utilized to repair
damaged or missing tissue and improve healing outcomes. More recently, processing of …

Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells

CM Dowling, C Herranz Ors, PA Kiely - Bioscience reports, 2014 - portlandpress.com
Increasing our knowledge of the mechanisms regulating cell proliferation, migration and
invasion are central to understanding tumour progression and metastasis. The local tumour …