In the pre-vaccine era, there was little information about clinical pertussis in adults, although
deaths were noted. Today Bordetella pertussis infection in adults is noted to cause a full …

The intensive use of pertussis vaccines has dramatically reduced the incidence of whooping
cough during the 20th century. However, recent outbreaks in countries with high vaccination …

Pertussis is a unique infectious disease in that it can be severe and fatal but occurs without
fever and other evidence of an inflammatory illness. The authors with others have studied …

Background Health-care personnel (HCP) are at risk for exposure to and possible
transmission of vaccine-preventable diseases. Receiving recommended vaccines is an …

Healthcare personnel (HCP) play a pivotal role in the transmission of contagious pathogens
in the healthcare setting, and HCP are themselves at risk for infection with such pathogens …

We develop a deterministic meta-population model to qualitatively capture some key
features of disease transmission between a community and its healthcare facility. We …

Acute exacerbations of chronic lung disease are usually associated with viral and bacterial
pathogens. They contribute to declining lung function, poor quality of life and exert an …

Increasing incidence has led to the re-appearance of pertussis as a public health problem in
developed countries. Pertussis infection is usually mild in vaccinated children and adults …

Pathogen attenuation to allow its safe administration to protect otherwise susceptible
subjects from infection is one of the earliest principles of vaccinology. At the same time that …

We assessed IgA antibodies and polymerase chain reaction (PCR) for diagnosis of pertussis
in nasopharyngeal aspiration (NPA) samples from outpatients in Australia. A total of 1700 …