Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology, target identification, and in the in vivo evaluation of novel …

There is intense interest in the development and application of animal models of CNS
disorders to explore pathology and molecular mechanisms, identify potential biomarkers …

Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder
caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in …

Huntington disease (HD) is an inherited neurodegenerative disease caused by a CAG
expansion in the HTT gene. Using yeast two-hybrid methods, we identified a large set of …

Oxidative stress plays a key role in late onset diseases including cancer and
neurodegenerative diseases such as Huntington disease. Therefore, uncovering regulators …

Cardiac remodelling and contractile dysfunction occur during both acute and chronic
disease processes including the accumulation of insoluble aggregates of misfolded amyloid …

Background Gene expression data provide invaluable insights into disease mechanisms. In
Huntington's disease (HD), a neurodegenerative disease caused by a tri-nucleotide repeat …

Motor slowing and forebrain white matter loss have been reported in premanifest
Huntington's disease (HD) prior to substantial striatal neuron loss. These findings raise the …

HD is caused by a mutation in the huntingtin gene that consists in a CAG repeat expansion
translated into an abnormal poly-glutamine (polyQ) tract in the huntingtin (Htt) protein. The …

Transcriptional dysregulation has been proposed to play a major role in the pathology of
Huntington's disease (HD). However, the mechanisms that cause selective downregulation …