During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …

Genome-wide association studies (GWASs) are the method most often used by geneticists
to interrogate the human genome, and they provide a cost-effective way to identify the …

Standard statistical approaches for prioritization of variants for functional testing in fine-
mapping studies either use marginal association statistics or estimate posterior probabilities …

Combinatorial structure and algorithms for deducing genetic recombination history,
represented by ancestral recombination graphs and other networks, and their role in the …

Understanding the genetic architecture of disease is an enormous challenge, and should be
guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual …

Insulin resistance (IR) is a general phenomenon of many physiological states, disease
states, and diseases. IR has been described in diabetes mellitus, obesity, infection, sepsis …

Genome-wide association studies (GWAS) have identified over 70 loci associated with type
2 diabetes (T2D). Most genetic variants associated with T2D are common variants with …

The prevalence of type 2 diabetes (T2D) is greater in populations of African descent
compared to European-descent populations. Genetic risk factors may underlie the disparity …

Despite the notion that there is a degree of commonality to the biological etiology of type 1
diabetes (T1D) and type 2 diabetes (T2D), the lack of overlap in the genetic factors …

Familial clustering and presumed genetic risk for type 2 diabetic (T2D) and non-diabetic end-
stage kidney disease (ESKD) appear strong in African Americans. Examination of exome …