Despite the advances in detection of and therapies for various tumors, high rates of
treatment failure and mortality still exist throughout the world. These high rates are mainly …

Background Improved clinical predictors for disease progression are needed for localised
prostate cancer, since only a subset of patients develop recurrent or refractory disease after …

Increased expression of specific calcium channels in some cancers and the role of calcium
signaling in proliferation and invasion have led to studies assessing calcium channel …

The growth adaptation of cancer cells to a hypoxic tumour microenvironment is mostly
regulated by hypoxia‐induced transcription factor HIF‐1. HIF‐1 transcriptional activity is …

CUB and sushi multiple domain protein 1 (CSMD1) is a candidate tumor suppressor gene.
The three members of CSMD family have very similar structures, each consisting of 14 CUB …

Background Recent evidence suggests that the prostate cancer (PCa)-specific up-regulation
of certain genes such as AMACR, EZH2, PSGR, PSMA and TRPM8 could be associated …

As the function of transient receptor potential melastatin member 8 (TRPM8) in
osteosarcoma is still unknown, we aim to investigate the possible effects and potential …

Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1
(GH/IGF-1) axis play an essential role in the normal development of the prostate but also in …

Prostate cancer (PCa) is the most common neoplasia among men in developed countries
and a leading cause of cancer-related morbidity and mortality. PCa is a very heterogeneous …

TweakR is a TNF receptor family member, whose natural ligand is the multifunctional
cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in …