Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

Biomarkers currently play an important role in the detection and management of patients
with several different types of gastrointestinal cancer, especially colorectal, gastric, gastro …

Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Metastatic colorectal cancer remains a lethal disease with a poor prognosis in the majority of
patients. Multiple drug combinations have been developed in recent years that have …

Colorectal cancer (CRC) is one of the most common human malignant diseases and the
second leading cause of cancer-related deaths worldwide. The treatment of advanced CRC …

Background: Ligands of transmembrane receptor tyrosine kinases have important roles in
cell proliferation, survival, migration and differentiation in solid tumours. We conducted this …

Abstract Background RAS-RAF-MEK-ERK and PI3K-AKT pathways form a significant
cascade for potential molecular target therapy in advanced cancer. The clinical significance …

Molecular evaluation of KRAS, BRAF, and PIK3CA mutation has become an important part
in colorectal carcinoma evaluation, and their alterations may determine the therapeutic …

Purpose: KRAS wild-type status is an imperfect predictor of sensitivity to anti-EGF receptor
(EGFR) monoclonal antibodies in colorectal cancer, motivating efforts to identify novel …

Background: Combined chemoradiation therapy is the gold standard in the treatment of
squamous cell anal cancer (SCAC). However, even if the response rate is very high, many …