Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
Identification and consequences of miRNA–target interactions—beyond repression of gene expression
Comparative genomics analyses and high-throughput experimental studies indicate that a
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance
Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as
sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA …
sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA …
Toehold‐initiated rolling circle amplification for visualizing individual microRNAs in situ in single cells
The ability to quantitate and visualize microRNAs (miRNAs) in situ in single cells would
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …
Global analyses of the effect of different cellular contexts on microRNA targeting
MicroRNA (miRNA) regulation clearly impacts animal development, but the extent to which
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
Miravirsen (SPC3649) can inhibit the biogenesis of miR-122
LFR Gebert, MAE Rebhan, SEM Crivelli… - Nucleic acids …, 2014 - academic.oup.com
MicroRNAs (miRNAs) are short noncoding RNAs, which bind to messenger RNAs and
regulate protein expression. The biosynthesis of miRNAs includes two precursors, a primary …
regulate protein expression. The biosynthesis of miRNAs includes two precursors, a primary …
Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets
V Kameswaran, NC Bramswig, LB McKenna, M Penn… - Cell metabolism, 2014 - cell.com
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …
MicroRNA-7a regulates pancreatic β cell function
M Latreille, J Hausser, I Stützer… - The Journal of …, 2014 - Am Soc Clin Investig
Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following
pathological stress and are the underlying cause of several disease conditions. In …
pathological stress and are the underlying cause of several disease conditions. In …
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs
Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …
key current challenges in molecular biology. Although gene expression and chromatin state …
TH1/TH2 cell differentiation and molecular signals
The distinctive differentiated states of the CD4+ T helper cells are determined by the set of
transcription factors and the genes transcribed by the transcription factors. In vitro induction …
transcription factors and the genes transcribed by the transcription factors. In vitro induction …