Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

Binding of proteins to particular DNA sites across the genome is a primary determinant of
specificity in genome maintenance and gene regulation. DNA-binding specificity is encoded …

Abstract The Protein Data Bank archive was established in 1971, and recently celebrated its
40th anniversary (Berman et al. in Structure 20: 391, 2012). An analysis of interrelationships …

DNA structure functions as an overlapping code to the DNA sequence. Rapid progress in
understanding the role of DNA structure in gene regulation, DNA damage recognition and …

Exposure to the ultraviolet component of sunlight causes DNA damage, which subsequently
leads to mutations, cellular transformation, and cell death. DNA photoproducts with (6-4) …

HU, one of the major nucleoid-associated proteins, interacts with the minor groove of DNA in
a nonspecific manner to induce DNA bending or to stabilize bent DNA. In this study, crystal …

To investigate the principles driving recognition between proteins and DNA, we analyzed
more than thousand crystal structures of protein/DNA complexes. We classified protein and …

A Tale of Chromatin and Transcription in 100 Structures: Cell Skip to Main Content
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The dynamical properties of water at protein–water interfaces are unlike those in the bulk.
Here we utilize molecular dynamics simulations to study water dynamics in interstitial …

We investigate the role of water molecules in 89 protein–RNA complexes taken from the
Protein Data Bank. Those with tRNA and single-stranded RNA are less hydrated than with …