Determinants of GH resistance in malnutrition

PK Fazeli, A Klibanski - J Endocrinol, 2014 - joe.bioscientifica.com
States of undernutrition are characterized by GH resistance. Decreased total energy intake,
as well as isolated protein–calorie malnutrition and isolated nutrient deficiencies, result in …

Anorexia nervosa and bone metabolism

PK Fazeli, A Klibanski - Bone, 2014 - Elsevier
Anorexia nervosa (AN) is a psychiatric disorder characterized by self-induced starvation with
a lifetime prevalence of 2.2% in women. The most common medical co-morbidity in women …

[HTML][HTML] Use of pegvisomant in acromegaly. An Italian Society of Endocrinology guideline

A Giustina, MR Ambrosio, P Beck Peccoz… - Journal of …, 2014 - Springer
Acromegaly management is a significant challenge for endocrinologists. The Acromegaly
Consensus Group developed several statements on the management of acromegaly and …

Therapy of acromegalic patients exacerbated by concomitant type 2 diabetes requires higher pegvisomant doses to normalise IGF1 levels

M Droste, J Domberg, M Buchfelder… - European journal of …, 2014 - academic.oup.com
Objective Acromegaly is associated with an increased prevalence of glucose metabolism
disorders. Clinically confirmed diabetes mellitus is observed in approximately one quarter of …

Intraperitoneal insulin infusion: treatment option for type 1 diabetes resulting in beneficial endocrine effects beyond glycaemia

PR Van Dijk, SJJ Logtenberg, ROB Gans… - Clinical …, 2014 - Wiley Online Library
Continuous intraperitoneal insulin infusion (CIPII) is a treatment option for patients with type
1 diabetes mellitus who fail to reach adequate glycaemic control despite intensive …

Bone metabolism in anorexia nervosa

PK Fazeli, A Klibanski - Current osteoporosis reports, 2014 - Springer
Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is
characterized by self-imposed, chronic nutritional deprivation and distorted body image. AN …

Insulin growth factor binding proteins as therapeutic targets in type 2 diabetes

R Hjortebjerg, A Flyvbjerg, J Frystyk - Expert opinion on therapeutic …, 2014 - Taylor & Francis
Introduction: The signaling pathways of the insulin-like growth factors (IGFs) have been
implicated in the aetiology of type 2 diabetes (T2D) and a number of therapeutic modalities …

Relationship among insulin resistance, growth hormone, and insulin‐like growth factor I concentrations in diestrous Swedish Elkhounds

EM Strage, MS Lewitt, JM Hanson… - Journal of veterinary …, 2014 - Wiley Online Library
Background In the dog, the normal estrous cycle includes a prolonged luteal phase.
Progesterone stimulates local canine mammary growth hormone (GH) production, which …

Intraperitoneal insulin delivery to patients with type 1 diabetes results in higher serum IGF‐I bioactivity than continuous subcutaneous insulin infusion

CA Hedman, J Frystyk, T Lindström… - Clinical …, 2014 - Wiley Online Library
Summary Objective Type 1 diabetes (T 1 D) is associated with low IGF‐I and altered levels
of IGF‐binding proteins (IGFBP s) in plasma. This may be of importance for insulin sensitivity …

[HTML][HTML] Effect of ip insulin administration on IGF1 and IGFBP1 in type 1 diabetes

PR van Dijk, SJJ Logtenberg, KH Groenier… - Endocrine …, 2014 - ec.bioscientifica.com
In type 1 diabetes mellitus (T1DM), low concentrations of IGF1 and high concentrations of
IGF-binding protein 1 (IGFBP1) have been reported. It has been suggested that these …