[HTML][HTML] DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios
C Månsson, V Kakkar, E Monsellier, Y Sourigues… - Cell stress and …, 2014 - Elsevier
Expanded polyglutamine (polyQ) stretches lead to protein aggregation and severe
neurodegenerative diseases. A highly efficient suppressor of polyQ aggregation was …
neurodegenerative diseases. A highly efficient suppressor of polyQ aggregation was …
[PDF][PDF] DNAJB6 fails to prevent the nucleation of intracellular polyQ proteins mediated by extracellular purified polyQ-peptide fragments
V Kakkar - core.ac.uk
Huntington's disease (HD) is associated with protein aggregates that also hallmark almost
all the major neurodegenerative diseases known. The aggregate formation is thought to be …
all the major neurodegenerative diseases known. The aggregate formation is thought to be …
DNAJ proteins: more than just “co-chaperones”: Implicaties voor eiwit-aggregatie ziektes
V Kakkar - 2014 - research.rug.nl
In order to be biologically active, every nascent polypeptide emerging from the ribosomes
should fold and acquire its native conformation. Non-native conformations lead to drastic …
should fold and acquire its native conformation. Non-native conformations lead to drastic …
[PDF][PDF] DNAJB6 is a peptide chaperone that suppresses initiation of aggregation mediated by polyglutamine containing polypeptide fragments
J Hageman, V Kakkar, C Månsson… - DNAJ proteins: more …, 2014 - research.rug.nl
As explained in Chapter 2, misfolding and aggregation are associated with cytotoxicity in
several protein folding diseases and large network of molecular chaperones ensures protein …
several protein folding diseases and large network of molecular chaperones ensures protein …