The multimodal properties of the human somatosensory system continue to be unravelled.
There is mounting evidence that one of these submodalities—touch—has another …

The skin is our largest sensory organ, transmitting pain, temperature, itch, and touch
information to the central nervous system. Touch sensations are conveyed by distinct …

The visualization of molecularly labeled structures within large intact tissues in three
dimensions is an area of intense focus. We describe a simple, rapid, and inexpensive …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Human C-tactile (CT) afferents respond vigorously to gentle skin stroking and have gained
attention for their importance in social touch. Pharmacogenetic activation of the mouse CT …

The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

Transit-amplifying cells (TACs) are an early intermediate in tissue regeneration. Here, using
hair follicles (HFs) as a paradigm, we show that emerging TACs constitute a signaling center …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The peripheral terminals of primary nociceptive neurons play an essential role in pain
detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and …

In sensory neurons, mechanotransduction is sensitive, fast and requires mechanosensitive
ion channels. Here we develop a new method to directly monitor mechanotransduction at …