Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering

Y Jiang, J Chen, C Deng, EJ Suuronen, Z Zhong - Biomaterials, 2014 - Elsevier
Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for
sustained protein release, targeted drug delivery, and tissue engineering due to excellent …

25th anniversary article: designer hydrogels for cell cultures: a materials selection guide

J Thiele, Y Ma, SMC Bruekers, S Ma… - Advanced …, 2014 - Wiley Online Library
Cell culturing, whether for tissue engineering or cell biology studies, always involves placing
cells in a non‐natural environment and no material currently exist that can mimic the entire …

The thiol-Michael addition click reaction: a powerful and widely used tool in materials chemistry

DP Nair, M Podgorski, S Chatani, T Gong… - Chemistry of …, 2014 - ACS Publications
The key attribute of the thiol-Michael addition reaction that makes it a prized tool in materials
science is its modular “click” nature, which allows for the implementation of this highly …

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

W Tang, ML Becker - Chemical Society Reviews, 2014 - pubs.rsc.org
Peptides that comprise the functional subunits of proteins have been conjugated to versatile
materials (biomolecules, polymers, surfaces and nanoparticles) in an effort to modulate cell …

On the biodegradability of polyethylene glycol, polypeptoids and poly (2-oxazoline) s

J Ulbricht, R Jordan, R Luxenhofer - Biomaterials, 2014 - Elsevier
Despite being the gold standard of hydrophilic biomaterials and well known sensitivity of
polyethylene glycol (PEG) against oxidative degradation, very little information on the …

Hydrogels for tissue engineering and regenerative medicine

JA Hunt, R Chen, T van Veen, N Bryan - Journal of Materials Chemistry …, 2014 - pubs.rsc.org
Injectable hydrogels have become an incredibly prolific area of research in the field of tissue
engineering and regenerative medicine, because of their high water content, mechanical …

Smart hydrogels as functional biomimetic systems

HL Lim, Y Hwang, M Kar, S Varghese - Biomaterials Science, 2014 - pubs.rsc.org
Stimuli-responsive (smart) hydrogels have attracted widespread attention as biomimetic
systems due to their ability to respond to subtle changes in external and internal stimuli …

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

MK Nguyen, E Alsberg - Progress in polymer science, 2014 - Elsevier
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of
their ability to present sustained, localized and controlled release of bioactive factors …

Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications

Z Li, BH Tan - Materials Science and Engineering: C, 2014 - Elsevier
Polycaprolactone (PCL) and its copolymers are a type of hydrophobic aliphatic polyester
based on hydroxyalkanoic acids. They possess exceptional qualities: biocompatibility; FDA …

Avidity-controlled hydrogels for injectable co-delivery of induced pluripotent stem cell-derived endothelial cells and growth factors

W Mulyasasmita, L Cai, RE Dewi, A Jha… - Journal of Controlled …, 2014 - Elsevier
To translate recent advances in induced pluripotent stem cell biology to clinical regenerative
medicine therapies, new strategies to control the co-delivery of cells and growth factors are …