When astrocytes become harmful: functional and inflammatory responses that contribute to Alzheimer's disease
E Avila-Muñoz, C Arias - Ageing research reviews, 2014 - Elsevier
A growing body of research suggests that astrocytes play roles as contributors to the
pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that …
pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that …
[HTML][HTML] Nicotinic acetylcholine receptors in human genetic disease
CP Schaaf - Genetics in Medicine, 2014 - Elsevier
Nicotinic acetylcholine receptors represent a family of ligand-gated ion channels that are
widely expressed in the central and peripheral nervous systems. To date, 16 genes …
widely expressed in the central and peripheral nervous systems. To date, 16 genes …
Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status
Alzheimer's disease (AD) is the most common form of dementia among older persons.
Pathognomonic hallmarks of the disease include the development of amyloid senile plaques …
Pathognomonic hallmarks of the disease include the development of amyloid senile plaques …
Treatment of cognitive disorders with (R)-7-chloro-N-(quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
R Chesworth, G Shapiro, G Koenig - US Patent 8,815,933, 2014 - Google Patents
Abstract (R)-7-chloro-N-(quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide has been
found to have procognitive effects in humans at unexpectedly low doses. Thus,(R)-7-chloro …
found to have procognitive effects in humans at unexpectedly low doses. Thus,(R)-7-chloro …
Treatment of cognitive disorders with (R)-7-chloro-N-(quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
R Chesworth, G Shapiro, G Koenig - US Patent 8,642,638, 2014 - Google Patents
Abstract (R)-7-chloro-N-(quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide has been
found to have procognitive effects in humans at unexpectedly low doses. Thus,(R)-7-chloro …
found to have procognitive effects in humans at unexpectedly low doses. Thus,(R)-7-chloro …
Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets
S Keihan Falsafi, S Roßner, M Ghafari, M Groessl… - Amino acids, 2014 - Springer
Although Alzheimer disease (AD) has been linked to defects in major brain receptors,
studies thus far have been limited to the determination of receptor subunits or specific ligand …
studies thus far have been limited to the determination of receptor subunits or specific ligand …
Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide hydrochloride monohydrate
P Oliver-Shaffer, G Shapiro, R Chesworth… - US Patent …, 2014 - Google Patents
US8710227B2 - Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide
hydrochloride monohydrate - Google Patents US8710227B2 - Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide …
hydrochloride monohydrate - Google Patents US8710227B2 - Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide …
[PDF][PDF] Expression der Alpha4-Untereinheit des nikotinischen Acetylcholinrezeptors im temporalen Kortex bei Morbus Parkinson mit und ohne Demenz
A Plamper - 2014 - repository.publisso.de
Among other ligand-gated ion channels such as GABAA, GABAC, glycine or 5HT-3
serotonin receptors, nicotinic acetylcholine receptors (nAChR) are an important member of …
serotonin receptors, nicotinic acetylcholine receptors (nAChR) are an important member of …
2-heteroarylcarboxylic acid amides
M Hendrix, FG Böβ, C Erb, T Fleβner… - US Patent …, 2014 - Google Patents
US8884017B2 - 2-heteroarylcarboxylic acid amides - Google Patents US8884017B2 - 2-heteroarylcarboxylic
acid amides - Google Patents 2-heteroarylcarboxylic acid amides Download PDF Info …
acid amides - Google Patents 2-heteroarylcarboxylic acid amides Download PDF Info …