Branched-chain amino acids (BCAAs) are important nutrient signals that have direct and
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …

Fatty acids (FAs) are essential elements of all cells and have significant roles as energy
substrates, components of cellular structure and signalling molecules. The storage of excess …

Igniting thermogenesis within white adipose tissue (ie, promoting expression and activity of
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …

Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal
activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high …

Induction of beige cells causes the browning of white fat and improves energy metabolism.
However, the central mechanism that controls adipose tissue browning and its physiological …

The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and
diabetes remain unclear. Here we show that induction of the unfolded protein response …

Background: An in-depth understanding of the fundamental principles that regulate thyroid
hormone homeostasis is critical for the development of new diagnostic and treatment …

We have recently shown that the non-coding RNA, steroid receptor RNA activator (SRA),
functions as a transcriptional coactivator of PPARγ and promotes adipocyte differentiation in …

Homeostatic temperature regulation is fundamental to mammalian physiology and is
controlled by acute and chronic responses of local, endocrine and nervous regulators. Here …

The circadian system is primarily entrained by the ambient light environment and is
fundamentally linked to metabolism. Mounting evidence suggests a causal relationship …