Liver disease is associated with qualitative and quantitative changes in the intestinal
microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an …

Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction …

To assess centrally mediated analgesic mechanisms in clinical trials with pain patients,
objective standardized methods such as electroencephalography (EEG) has many …

Background Longlasting and unbearable pain is the most common and striking symptom of
chronic pancreatitis. Accordingly, pain relief and improvement in patients' quality of life are …

Introduction: Although medicinal cannabis has been used for many centuries, the
therapeutic potential of delta-9-tetrahydrocannabinol (Δ9-THC; international non-proprietary …

Pregabalin is a γ-aminobutyric acid analogue that is primarily prescribed in psychiatry for
management of generalized anxiety disorder. The belief in its low potential for abuse has …

Pregabalin is a GABA analogue that is primarily prescribed in psychiatry for management of
generalized anxiety disorder. The belief in its low potential for abuse has placed it in a …