Long non-coding RNAs: modulators of nuclear structure and function
JH Bergmann, DL Spector - Current opinion in cell biology, 2014 - Elsevier
Long non-coding (lnc) RNAs are emerging key factors in the regulation of various cellular
processes. In the nucleus, these include the organization of nuclear sub-structures, the …
processes. In the nucleus, these include the organization of nuclear sub-structures, the …
Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation
AV Gendrel, E Heard - Annual review of cell and developmental …, 2014 - annualreviews.org
In mammals, the process of X-chromosome inactivation ensures equivalent levels of X-
linked gene expression between males and females through the silencing of one of the two …
linked gene expression between males and females through the silencing of one of the two …
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it
remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h …
remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h …
[HTML][HTML] Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes
LL Hall, DM Carone, AV Gomez, HJ Kolpa, M Byron… - Cell, 2014 - cell.com
Recent studies recognize a vast diversity of noncoding RNAs with largely unknown
functions, but few have examined interspersed repeat sequences, which constitute almost …
functions, but few have examined interspersed repeat sequences, which constitute almost …
The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network
During early development of female mouse embryos, both X chromosomes are transiently
active. X gene dosage is then equalized between the sexes through the process of X …
active. X gene dosage is then equalized between the sexes through the process of X …
[HTML][HTML] X-chromosome inactivation in development and cancer
R Chaligné, E Heard - FEBS letters, 2014 - Elsevier
X-chromosome inactivation represents an epigenetics paradigm and a powerful model
system of facultative heterochromatin formation triggered by a non-coding RNA, Xist, during …
system of facultative heterochromatin formation triggered by a non-coding RNA, Xist, during …
Variable escape from X‐chromosome inactivation: Identifying factors that tip the scales towards expression
In humans over 15% of X‐linked genes have been shown to 'escape'from X‐chromosome
inactivation (XCI): they continue to be expressed to some extent from the inactive X …
inactivation (XCI): they continue to be expressed to some extent from the inactive X …
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis
Y Luo, X Lu, H Xie - BioMed research international, 2014 - Wiley Online Library
DNA methylation primarily occurs on CpG dinucleotides and plays an important role in
transcriptional regulations during tissue development and cell differentiation. Over 25% of …
transcriptional regulations during tissue development and cell differentiation. Over 25% of …
L1 retrotransposons, cancer stem cells and oncogenesis
Retrotransposons have played a central role in human genome evolution. The accumulation
of heritable L1, Alu and SVA retrotransposon insertions continues to generate structural …
of heritable L1, Alu and SVA retrotransposon insertions continues to generate structural …
MOF-associated complexes ensure stem cell identity and Xist repression
Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are
frequently misregulated in cancers. Here, we study the regulatory potential of MYST1-(MOF) …
frequently misregulated in cancers. Here, we study the regulatory potential of MYST1-(MOF) …