[HTML][HTML] Physiological and pathological phosphorylation of tau by Cdk5
T Kimura, K Ishiguro, S Hisanaga - Frontiers in molecular …, 2014 - frontiersin.org
Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological
events in Alzheimer's disease (AD) and other related neurodegenerative diseases, including …
events in Alzheimer's disease (AD) and other related neurodegenerative diseases, including …
Cdk5 activity in the brain–multiple paths of regulation
ABSTRACT Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent
kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is …
kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is …
C dk5 regulates multiple cellular events in neural development, function and disease
T Kawauchi - Development, growth & differentiation, 2014 - Wiley Online Library
Cyclin‐dependent kinases (CDK s) generally regulate cell proliferation in dividing cells,
including neural progenitors. In contrast, an unconventional CDK, C dk5, is predominantly …
including neural progenitors. In contrast, an unconventional CDK, C dk5, is predominantly …
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
High sugar consumption and diabetes increase the risk of developing Alzheimer's disease
(AD) by unknown mechanisms. Using an animal model of AD, here we show that high …
(AD) by unknown mechanisms. Using an animal model of AD, here we show that high …
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity
X Zhang, H Zhang, H Shao, Q Xue, B Yu - PloS one, 2014 - journals.plos.org
Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity
participates in the regulation of nociceptive signaling. Like binding with the activators (P35 …
participates in the regulation of nociceptive signaling. Like binding with the activators (P35 …
Regulation of neuronal cytoskeletal protein phosphorylation in neurodegenerative diseases
P Rudrabhatla - Journal of Alzheimer's disease, 2014 - content.iospress.com
Neuronal cytoskeletal proteins such as neurofilaments (NFs) and tau are aberrantly and
hyperphosphorylated in neurodegeneration. Under normal physiological conditions, NFs …
hyperphosphorylated in neurodegeneration. Under normal physiological conditions, NFs …
Cdk5/p35 is required for motor coordination and cerebellar plasticity
X He, M Ishizeki, N Mita, S Wada, Y Araki… - Journal of …, 2014 - Wiley Online Library
Previous studies have implicated the role of Purkinje cells in motor learning and the
underlying mechanisms have also been identified in great detail during the last decades …
underlying mechanisms have also been identified in great detail during the last decades …
Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia
Cdk5 is a member of the cyclin-dependent kinase (Cdk) family that plays a role in various
neuronal activities including brain development, synaptic regulation, and …
neuronal activities including brain development, synaptic regulation, and …
CDK5 在细胞中的调控机理
李凌燕， 乌兰 - 山西农业科学, 2014 - cqvip.com
CDK5 是一个多功能的丝氨酸或苏氨酸蛋白激酶, 最主要的功能是调控发育的中枢神经系统的
神经迁移. 其与调节亚基P35, P39 或P25 的结合是保持活性及其调控功能最基本的策略. 因此 …
神经迁移. 其与调节亚基P35, P39 或P25 的结合是保持活性及其调控功能最基本的策略. 因此 …
Interplay Between Viral and Cellular Factors Determines the Fate of Herpes Simplex Virus type I Infection
H Mabrouk-Mostafa - 2014 - kuscholarworks.ku.edu
The herpes simplex virus type I (HSV-1) is a major human pathogen that infects the majority
of the world's population. The life cycle of HSV-1 is controlled by interactions with its hosts …
of the world's population. The life cycle of HSV-1 is controlled by interactions with its hosts …