The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway
is activated by upstream genomic events and/or activation of multiple signaling events in …

Tumors constitute highly suppressive microenvironments in which infiltrating T cells are"
exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory …

This report presents 2012 US final mortality data on deaths and death rates by demographic
and medical characteristics. These data provide information on mortality patterns among …

Recent genomic analyses of pathologically defined tumor types identify" within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across …

Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Recent technologies have made it cost-effective to collect diverse types of genome-wide
data. Computational methods are needed to combine these data to create a comprehensive …

Multiplexed quantitation via isobaric chemical tags (eg, tandem mass tags (TMT) and
isobaric tags for relative and absolute quantitation (iTRAQ)) has the potential to revolutionize …

Several bacterial species have been implicated in the development of colorectal carcinoma
(CRC), but CRC‐associated changes of fecal microbiota and their potential for cancer …

In this Timeline, we describe the characteristics of tumour antigens that are recognized by
spontaneous T cell responses in cancer patients and the paths that led to their identification …