The microbiota plays a fundamental role on the induction, training, and function of the host
immune system. In return, the immune system has largely evolved as a means to maintain …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

Microbes or danger signals trigger inflammasome sensors, which induce polymerization of
the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase …

Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …

The human gut harbors> 100 trillion microbial cells, which influence the nutrition,
metabolism, physiology, and immune function of the host. Here, we review the quantitative …

Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in
the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently …

CD 161++ CD 8+ T cells represent a novel subset that is dominated in adult peripheral
blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a …

Research on innate immune signaling and regulation has recently focused on pathogen
recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense …

Background Hyaluronan is a critical component of extracellular matrix with several different
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …