Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

One of the great strengths of the mouse model is the wide array of genetic tools that have
been developed. Striking examples include methods for directed modification of the …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …

DNA methylation is a key epigenetic modification involved in regulating gene expression
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …

For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

Naïve and primed pluripotent states retain distinct molecular properties, yet limited
knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N …

Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …

Induced pluripotency is a promising avenue for disease modeling and therapy, but the
molecular principles underlying this process, particularly in human cells, remain poorly …