In order to observe and quantify long-range neuronal connections in intact mouse brain by
light microscopy, it is first necessary to clear the brain, thus suppressing refractive-index …

The KRAS gene is commonly mutated in human cancers, rendering the encoded small
GTPase constitutively active and oncogenic. This gene has the unusual feature of being …

Adeno-associated virus (AAV) is a dependent virus of the family Parvoviridae. The gene
expression and replication of AAV and derived recombinant AAV (rAAV) vectors are …

The raphe nuclei provide serotonergic innervation widely in the brain, thought to mediate a
variety of neuromodulatory effects. The mammalian olfactory bulb (OB) is a prominent …

In this study, a universal protein expression enhancement RNA tool, termed RNAe, was
developed by modifying a recently discovered natural long non-coding RNA. At the moment …

Successful therapeutic protein production in vitro and in vivo requires efficient and long-term
transgene expression supported by optimized vector and transgene cis-regulatory sequence …

Ticks transmit numerous pathogens, including borreliae, which cause Lyme disease. Tick
saliva contains a complex mix of anti-host defense factors, including the immunosuppressive …

Adeno-associated virus (AAV) nonstructural proteins Rep78 and Rep68 carry out all DNA
transactions that regulate the AAV life cycle. They share two multifunctional domains: an N …

Crossing the blood–brain and the blood–cerebrospinal fluid barriers (BCSFB) is one of the
fundamental challenges in the development of new therapeutic molecules for brain …

Lipid rafts, specialized membrane microdomains in the plasma membrane rich in cholesterol
and sphingolipids, are hot spots for a number of important cellular processes. The novel …