Reliably pinpointing which specific amino acid residues form the interface (s) between a
protein and its binding partner (s) is critical for understanding the structural and …

SMC/kleisin complexes form elongated annular structures, which are critical for
chromosome segregation, genome maintenance, and the regulation of gene expression. We …

We present an updated and integrated version of our widely used protein–protein docking
and binding affinity benchmarks. The benchmarks consist of non-redundant, high-quality …

Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and
asthma exacerbations compared with other rhinoviruses. The cellular receptor for these …

A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism
involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide …

Organisms are adapted to the relentless cycles of day and night, because they evolved
timekeeping systems called circadian clocks, which regulate biological activities with~ 24 …

To maintain cellular structure and integrity during division, Gram-negative bacteria must
carefully coordinate constriction of a tripartite cell envelope of inner membrane …

Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underlie the
pathogenesis and chemoresistance of∼ 30% of all human tumors, yet the development of …

Background & Aims Defects in intestinal innate defense systems predispose patients to
inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by …

Prions cause transmissible spongiform encephalopathies for which no treatment exists.
Prions consist of PrPSc, a misfolded and aggregated form of the cellular prion protein …