[HTML][HTML] Animal models, learning lessons to prevent and treat neonatal chronic lung disease

AH Jobe - Frontiers in medicine, 2015 - frontiersin.org
Bronchopulmonary dysplasia (BPD) is a unique injury syndrome caused by prolonged injury
and repair imposed on an immature and developing lung. The decreased septation and …

Impaired pulmonary vascular development in bronchopulmonary dysplasia

CD Baker, SH Abman - Neonatology, 2015 - karger.com
Bronchopulmonary dysplasia (BPD), the chronic lung disease associated with preterm birth,
results from the disruption of normal pulmonary vascular and alveolar growth. Though BPD …

Off-label use of inhaled nitric oxide after release of NIH consensus statement

MA Ellsworth, MN Harris, WA Carey, AR Spitzer… - …, 2015 - publications.aap.org
BACKGROUND: Inhaled nitric oxide (iNO) therapy is an off-label medication in infants< 34
weeks' gestational age. In 2011, the National Institutes of Health released a statement …

Genetic predisposition to bronchopulmonary dysplasia

CV Lal, N Ambalavanan - Seminars in perinatology, 2015 - Elsevier
The objective of this study is to review the candidate gene and genome-wide association
studies relevant to bronchopulmonary dysplasia, and to discuss the emerging …

[HTML][HTML] Drug therapy for the prevention and treatment of bronchopulmonary dysplasia

A Iyengar, JM Davis - Frontiers in pharmacology, 2015 - frontiersin.org
Introduction: As more infants are surviving at younger gestational ages, bronchopulmonary
dysplasia (BPD) remains as a frequent neonatal complication occurring after preterm birth …

Inhaled nitric oxide in preterm infants with prolonged preterm rupture of the membranes: a case series

J Semberova, SM O'Donnell, J Franta… - Journal of Perinatology, 2015 - nature.com
The available evidence does not support the routine use of inhaled nitric oxide (iNO) in the
care of premature infants. We present a case series of 22 preterm infants born after …

Inhaled nitric oxide for the preterm infant: evidence versus practice

NN Finer, N Evans - Pediatrics, 2015 - publications.aap.org
In the current issue of the journal, Ellsworth1 et al report a small but significant increase
(from 5.0% to 6.2%) in the off-label use of inhaled nitric oxide (iNO) between 2009 and 2013 …

Neonatal medicines research: challenges and opportunities

J Samardzic, MA Turner, R Bax… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: The key feature of the newborn is its fast age-dependent maturation, resulting
in extensive variability in pharmacokinetics and-dynamics, further aggravated by newly …

[HTML][HTML] Adjunctive therapies for treatment of severe respiratory failure in neonates

L Gortner - Klinische Pädiatrie, 2015 - thieme-connect.com
Ergänzende Therapien bei Neugeborenen mit schwerem respiratorischen Versagen
monary interstitial emphysema and other forms of neonatal air leaks [10]. Pulmonary air …