Neurodevelopment, GABA system dysfunction, and schizophrenia
MJ Schmidt, K Mirnics - Neuropsychopharmacology, 2015 - nature.com
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …
Bleuler began documenting their findings. However, large clinical research efforts in recent …
Evidence of mitochondrial dysfunction within the complex genetic etiology of schizophrenia
Genetic evidence has supported the hypothesis that schizophrenia (SZ) is a polygenic
disorder caused by the disruption in function of several or many genes. The most common …
disorder caused by the disruption in function of several or many genes. The most common …
Cognitive decline preceding the onset of psychosis in patients with 22q11. 2 deletion syndrome
JAS Vorstman, EJ Breetvelt, SN Duijff, S Eliez… - JAMA …, 2015 - jamanetwork.com
Importance Patients with 22q11. 2 deletion syndrome (22q11DS) have an elevated (25%)
risk of developing schizophrenia. Recent reports have suggested that a subgroup of children …
risk of developing schizophrenia. Recent reports have suggested that a subgroup of children …
Comparative mapping of the 22q11. 2 deletion region and the potential of simple model organisms
A Guna, NJ Butcher, AS Bassett - Journal of neurodevelopmental …, 2015 - Springer
Abstract Background 22q11. 2 deletion syndrome (22q11. 2DS) is the most common micro-
deletion syndrome. The associated 22q11. 2 deletion conveys the strongest known …
deletion syndrome. The associated 22q11. 2 deletion conveys the strongest known …
miR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathways
JO Kim, DW Song, EJ Kwon, SE Hong, HK Song… - PLoS …, 2015 - journals.plos.org
MicroRNA (miRNA) is an endogenous non-coding RNA species that either inhibits RNA
translation or promotes degradation of target mRNAs. miRNAs often regulate cellular …
translation or promotes degradation of target mRNAs. miRNAs often regulate cellular …
Characterizing autism spectrum disorders by key biochemical pathways
M Subramanian, CK Timmerman, JL Schwartz… - Frontiers in …, 2015 - frontiersin.org
The genetic and phenotypic heterogeneity of autism spectrum disorders (ASD) presents a
substantial challenge for diagnosis, classification, research, and treatment. Investigations …
substantial challenge for diagnosis, classification, research, and treatment. Investigations …
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
J Kocerha, Y Dwivedi, KJ Brennand - Molecular psychiatry, 2015 - nature.com
The human genome project has revolutionized our understanding of the underlying
mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral …
mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral …
Development of cortical interneurons
J Chu, SA Anderson - Neuropsychopharmacology, 2015 - nature.com
Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the
development and function of cortical networks. Their inhibitory influences regulate both the …
development and function of cortical networks. Their inhibitory influences regulate both the …
Mitochondrial citrate transporter-dependent metabolic signature in the 22q11. 2 deletion syndrome
The congenital disorder 22q11. 2 deletion syndrome (22qDS), characterized by a
hemizygous deletion of 1.5–3 Mb on chromosome 22 at locus 11.2, is the most common …
hemizygous deletion of 1.5–3 Mb on chromosome 22 at locus 11.2, is the most common …
Whole-genome sequencing suggests schizophrenia risk mechanisms in humans with 22q11. 2 deletion syndrome
Abstract Chromosome 22q11. 2 microdeletions impart a high but incomplete risk for
schizophrenia. Possible mechanisms include genome-wide effects of DGCR8 …
schizophrenia. Possible mechanisms include genome-wide effects of DGCR8 …