Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …

Phosphoinositides are a collection of lipid messengers that regulate most subcellular
processes. Amongst the seven phosphoinositide species, the roles for phosphatidylinositol …

Chlamydia trachomatis is a leading cause of genital and ocular infections for which no
vaccine exists. Upon entry into host cells, C. trachomatis resides within a membrane-bound …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PI4, 5P 2) is an essential lipid messenger
with roles in all eukaryotes and most aspects of human physiology. By controlling the …

Lysosomal degradation is essential for the termination of EGF‐stimulated EGF receptor
(EGFR) signaling. This requires EGFR sorting to the intraluminal vesicles (ILVs) of multi …

The recruitment of inositol phosphatases to endocytic membranes mediates
dephosphorylation of PI (4, 5) P2, a phosphoinositide concentrated in the plasma …

The assembly of signaling complexes at the plasma membrane is required for the initiation
and propagation of cellular signaling upon cell activation. The class I PI3K and the …

Regenerative capacity of the brain is a variable trait within animals. Aquatic vertebrates such
as zebrafish have widespread ability to renew their brains upon damage, while mammals …

Phosphoinositides (PtdInsPs) are lipids that mediate a range of conserved cellular
processes in eukaryotes. These include the transduction of ligand binding to cell surface …

Receptors on cell membrane bind to their respective ligands and transduce intracellular
signals resulting in variety of effector functions. Membrane lipid composition determines the …