Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart
failure (HF) in older adults, particularly women, and is increasing in prevalence as the …

The aging population is increasing dramatically. Aging-associated stress simultaneously
drives proinflammatory remodeling, involving angiotensin II and other factors, in both the …

Background Oxidative stress is strongly associated with aging and age-related diseases and
plays a crucial role in endothelial dysfunction development. Aim To better understand the …

The incidence of stroke and myocardial infarction increases in aged patients and it is
associated with an adverse outcome. Considering the aging population and the increasing …

Regular physical exercise mediates health and longevity promotion involving Sirtuin 1
(SIRT1)-regulated pathways. The anti-aging activity of SIRT1 is achieved, at least in part, by …

Adipose tissue is a pivotal organ determining longevity, due largely to its role in maintaining
whole-body energy homeostasis and insulin sensitivity. SIRT1 is a NAD-dependent protein …

The sirtuins comprise a highly conserved family proteins present in virtually all species from
bacteria to mammals. Sirtuins are members of the highly conserved class III histone …

Recent evidence suggests that mitochondria are one of the main factors in the pathogenesis
in different organs including brain. The pathogenesis after brain damage is caused not only …

Bone marrow mesenchymal stem cells (BMSCs) have been shown to offer a wide variety of
cellular functions including the protective effects on damaged hearts. Here we investigated …

Physical exercise is associated with reduced risk of heart disease, type II diabetes mellitus,
and overall mortality. However, growing evidence shows that physical activity can also …