[HTML][HTML] Synchronization of biological clock neurons by light and peripheral feedback systems promotes circadian rhythms and health
A Ramkisoensing, JH Meijer - Frontiers in neurology, 2015 - frontiersin.org
In mammals, the suprachiasmatic nucleus (SCN) functions as a circadian clock that drives
24-h rhythms in both physiology and behavior. The SCN is a multicellular oscillator in which …
24-h rhythms in both physiology and behavior. The SCN is a multicellular oscillator in which …
Genetics of circadian rhythms
TS Andreani, TQ Itoh, E Yildirim… - Sleep medicine …, 2015 - sleep.theclinics.com
Almost all organisms organize their physiology, behavior, and metabolism according to the
24-hour solar cycle. Time-dependent changes in these parameters have evolved to allow …
24-hour solar cycle. Time-dependent changes in these parameters have evolved to allow …
[HTML][HTML] Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms
IT Lee, AS Chang, M Manandhar, Y Shan, J Fan… - Neuron, 2015 - cell.com
Circadian behavior in mammals is orchestrated by neurons within the suprachiasmatic
nucleus (SCN), yet the neuronal population necessary for the generation of timekeeping …
nucleus (SCN), yet the neuronal population necessary for the generation of timekeeping …
Chronic stress induces brain region-specific alterations of molecular rhythms that correlate with depression-like behavior in mice
Background Emerging evidence implicates circadian abnormalities as a component of the
pathophysiology of major depressive disorder (MDD). The suprachiasmatic nucleus (SCN) …
pathophysiology of major depressive disorder (MDD). The suprachiasmatic nucleus (SCN) …
Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior
J Huang, Z Zhong, M Wang, X Chen, Y Tan… - Journal of …, 2015 - Soc Neuroscience
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric
disorders in children and adults. While ADHD patients often display circadian abnormalities …
disorders in children and adults. While ADHD patients often display circadian abnormalities …
Variations in phase and amplitude of rhythmic clock gene expression across prefrontal cortex, hippocampus, amygdala, and hypothalamic paraventricular and …
LE Chun, ER Woodruff, S Morton… - Journal of biological …, 2015 - journals.sagepub.com
The molecular circadian clock is a self-regulating transcription/translation cycle of positive
(Bmal1, Clock/Npas2) and negative (Per1, 2, 3, Cry1, 2) regulatory components. While the …
(Bmal1, Clock/Npas2) and negative (Per1, 2, 3, Cry1, 2) regulatory components. While the …
[HTML][HTML] Circadian clock disruption in neurodegenerative diseases: cause and effect?
ES Musiek - Frontiers in pharmacology, 2015 - frontiersin.org
Disturbance of the circadian system, manifested as disrupted daily rhythms of physiologic
parameters such as sleep, activity, and hormone secretion, has long been observed as a …
parameters such as sleep, activity, and hormone secretion, has long been observed as a …
Emerging models for the molecular basis of mammalian circadian timing
CL Gustafson, CL Partch - Biochemistry, 2015 - ACS Publications
Mammalian circadian timekeeping arises from a transcription-based feedback loop driven
by a set of dedicated clock proteins. At its core, the heterodimeric transcription factor …
by a set of dedicated clock proteins. At its core, the heterodimeric transcription factor …
Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells
K Solocinski, J Richards, S All… - American Journal …, 2015 - journals.physiology.org
We have previously demonstrated that the circadian clock protein period (Per) 1
coordinately regulates multiple genes involved in Na+ reabsorption in renal collecting duct …
coordinately regulates multiple genes involved in Na+ reabsorption in renal collecting duct …
[HTML][HTML] The circadian clock controls sunburn apoptosis and erythema in mouse skin
Epidemiological studies of humans and experimental studies with mouse models suggest
that sunburn resulting from exposure to excessive UV light and damage to DNA confers an …
that sunburn resulting from exposure to excessive UV light and damage to DNA confers an …