Water-soluble ruthenium (II) complexes with chiral 4-(2, 3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G …

ZF Chen, QP Qin, JL Qin, J Zhou, YL Li… - Journal of Medicinal …, 2015 - ACS Publications
Three water-soluble ruthenium (II) complexes with chiral 4-(2, 3-dihydroxypropyl)-formamide
oxoaporphine (FOA) were synthesized and characterized. It was found that these ruthenium …

Biologically active [Pd 2 L 4] 4+ quadruply-stranded helicates: stability and cytotoxicity

SM McNeill, D Preston, JEM Lewis, A Robert… - Dalton …, 2015 - pubs.rsc.org
There is emerging interest in the anti-proliferative effects of metallosupramolecular systems
due to the different size and shape of these metallo-architectures compared to traditional …

Engineering gold nanoparticles with DNA ligands for selective catalytic oxidation of chiral substrates

P Zhan, ZG Wang, N Li, B Ding - ACS Catalysis, 2015 - ACS Publications
Noble metal nanoparticles are promising materials for heterogeneous enantioselective
catalysis because of their high surface-to-volume ratios, large concentrations of highly …

Synthesis, structure, stability and antimicrobial activity of a ruthenium (II) helicate derived from a bis-bidentate “click” pyridyl-1, 2, 3-triazole ligand

SV Kumar, WKC Lo, HJL Brooks, JD Crowley - Inorganica Chimica Acta, 2015 - Elsevier
Abstract A [Ru 2 L 3] 4+ ruthenium (II) triply-stranded helicate was synthesized from a bis-
bidentate “click” pyridyl-1, 2, 3-triazole ligand and RuCl 3 in good yield (58%). The helicate …

Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium (III) complex

S Lin, B He, C Yang, CH Leung, JL Mergny… - Chemical …, 2015 - pubs.rsc.org
In this study, we synthesized a series of 9 luminescent iridium (III) complexes and studied
their ability to function as luminescent probes for G-quadruplex DNA. The iridium (III) …

Binding Behaviors for Different Types of DNA G‐Quadruplexes: Enantiomers of [Ru(bpy)2(L)]2+ (L=dppz, dppz‐idzo)

S Shi, JH Xu, X Gao, HL Huang… - Chemistry–A European …, 2015 - Wiley Online Library
Polymorphic DNA G‐quadruplex recognition has attracted great interest in recent years. The
strong binding affinity and potential enantioselectivity of chiral [Ru (bpy) 2 (L)] 2+(L= dipyrido …

Cationic azacryptands as selective three-way DNA junction binding agents

J Novotna, A Laguerre, A Granzhan… - Organic & …, 2015 - pubs.rsc.org
DNA damaging agents are among the most powerful anticancer drugs currently in clinical
use. As an alternative to irreversible nucleobase damage and DNA strand breaks, the non …

Selective nuclei accumulation of ruthenium (II) complex enantiomers that target G-quadruplex DNA

D Sun, Y Liu, Q Yu, D Liu, Y Zhou, J Liu - Journal of Inorganic Biochemistry, 2015 - Elsevier
Different enantiomers exhibit large differences in their biological activity and/or toxicity, but
they rarely involve the relationship of the agents for molecular and cellular imaging with the …

Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices

J Malina, P Scott, V Brabec - Dalton Transactions, 2015 - pubs.rsc.org
Bulged structures have been identified in nucleic acids and have been shown to be linked to
biomolecular processes involved in numerous diseases. Thus, chemical agents with affinity …

Iron (II) supramolecular helicates condense plasmid DNA and inhibit vital DNA‐related enzymatic activities

J Malina, MJ Hannon, V Brabec - Chemistry–A European …, 2015 - Wiley Online Library
The dinuclear iron (II) supramolecular helicates [Fe2L3] Cl4 (L= C25H20N4) bind to DNA
through noncovalent (ie, hydrogen‐bonding, electrostatic) interactions and exhibit …