Refractory hypertension is an extreme phenotype of treatment failure defined as
uncontrolled blood pressure in spite of≥ 5 classes of antihypertensive agents, including …

Aims: Enhanced vascular ageing is associated with elevated central pulse pressure (cPP),
an independent predictor of cardiovascular (CV) events. Although antihypertensive …

Chronic kidney disease (CKD) is characterized by overactivation of the sympathetic nervous
system (SNS) that contributes to cardiovascular risk. Decreased nitric oxide (NO) …

Lack of elasticity in the central artery causes an increase in left ventricular (LV) afterload.
Although regular moderate-intensity endurance exercise improves cardiovascular function …

New Findings What is the central question of this study? Does ageing influence the
respiratory‐related bursting of muscle sympathetic nerve activity (MSNA) and the …

Aim. Metabolic syndrome is characterized by a cluster of atherosclerotic cardiovascular risk
factors. The cardioankle vascular index (CAVI) reflects arterial stiffness and may be used as …

Cardiovascular disease is the number one cause of deaths in most industrialized countries.
The most prominent change in the blood vessels that can contribute to the prevalence of …

Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to explore
functional connectivity (FC) between brain regions across neurological and psychiatric …

Intermittent hypoxia (IH) occurs in association with obstructive sleep apnea and is thought to
contribute to the pathogenesis of hypertension. The proposed mechanisms involved include …

INTRODUCTION: There is currently limited longitudinal data investigating the performance
and health-related influence of ultra-endurance training and participation. Cross-sectional …