Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity

A Dalla Mora, D Contini, S Arridge, F Martelli… - Biomedical optics …, 2015 - opg.optica.org
Light is a powerful tool to non-invasively probe highly scattering media for clinical
applications ranging from oncology to neurology, but also for molecular imaging, and quality …

Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics

A Dalla Mora, E Martinenghi, D Contini, A Tosi… - Optics express, 2015 - opg.optica.org
We present a proof of concept prototype of a time-domain diffuse optics probe exploiting a
fast Silicon PhotoMultiplier (SiPM), featuring a timing resolution better than 80 ps, a fast tail …

Mechanically switchable solid inhomogeneous phantom for performance tests in diffuse imaging and spectroscopy

A Pifferi, A Torricelli, R Cubeddu… - … of biomedical optics, 2015 - spiedigitallibrary.org
A mechanically switchable solid inhomogeneous phantom simulating localized absorption
changes was developed and characterized. The homogeneous host phantom was made of …

Spectrally resolved single-photon timing of silicon photomultipliers for time-domain diffuse spectroscopy

E Martinenghi, A Dalla Mora, D Contini… - IEEE Photonics …, 2015 - ieeexplore.ieee.org
We characterized the single-photon timing response function of various silicon
photomultipliers (SiPMs) over a broad (500-1100 nm) spectral range. We selected two SiPM …

[HTML][HTML] Effects of increasing neuromuscular electrical stimulation current intensity on cortical sensorimotor network activation: a time domain fNIRS study

M Muthalib, R Re, L Zucchelli, S Perrey, D Contini… - PLoS …, 2015 - journals.plos.org
Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked
movements activate regions of the cortical sensorimotor network, including the primary …

Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements

F Martelli, S Del Bianco, L Spinelli… - … of biomedical optics, 2015 - spiedigitallibrary.org
In this work, we have tested the optimal estimation (OE) algorithm for the reconstruction of
the optical properties of a two-layered liquid tissue phantom from time-resolved single …

Study of inks used in biomedical optics phantoms: stability and ageing

PA Pardini, MVW Serra… - Journal of Near …, 2015 - opg.optica.org
Inks are the most common absorbers added in phantoms for biomedical optics experiments.
Due to the small quantities required, it is usual to prepare dilutions in distilled water and to …

Development of traceable measurement of the diffuse optical properties of solid reference standards for biomedical optics at National Institute of Standards and …

P Lemaillet, JP Bouchard, DW Allen - Applied optics, 2015 - opg.optica.org
The development of a national reference instrument dedicated to the measurement of the
scattering and absorption properties of solid tissue-mimicking phantoms used as reference …

Non-contact scanning time-domain functional optical imaging of the adult human brain

H Wabnitz, M Mazurenka, K Fuchs… - … on Biomedical Optics, 2015 - opg.optica.org
We developed a novel scanning system that relies on gated detection of late photons at
short source-detector separation, enabling the recording of absorption changes in deep …

Dynamic mapping of the human brain by time-resolved NIRS techniques

A Liebert, M Kacprzak, D Milej, W Becker… - … Time-Correlated Single …, 2015 - Springer
Dynamic mapping of the human brain by time-resolved near-infrared-spectroscopy (trNIRS),
or functional NIRS (fNIRS), is based on the injection of picosecond or sub-nanosecond laser …