Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of
reward‐related behaviors that are negatively affected in states of altered dopamine …

In prior studies, we described the differential organization of corticostriatal and
thalamostriatal inputs to the spines of direct pathway (dSPNs) and indirect pathway striatal …

There is significant evidence that in addition to reward-punishment based decision making,
the Basal Ganglia (BG) contributes to risk-based decision making (Balasubramani et al.,) …

The nucleus accumbens (Nac) mediates the reinforcing and motor stimulating properties of
psychostimulants. It receives dopaminergic afferents from the ventral midbrain and is divided …

The growing use of cannabis in western societies is of significant concern especially
considering that its consumption has increased in teens who are most at risk for developing …

Low threshold spiking interneurons (LTSIs) and cholinergic interneurons are subtypes of
striatal neurons that play an important role in modulation of final striatal output. This thesis …

The D1R and D2R dopamine receptor (DAR) subtypes represent the two most abundant
and highly targeted DARs, but the precise mechanisms of drug action at the molecular level …

The research work presented in this thesis proposes a computational model that reconciles
the various functions of neuromodulators dopamine (DA) and serotonin (5HT) in the basal …

Stimuli that repeatedly are paired with reward, ie, appetitive conditioned stimuli (CSs), have
the remarkable ability to potentiate operant responding to obtain the reward, a behavioral …

El sistema renina-angiotensina (SRA) ha sido considerado tradicionalmente como un
sistema circulante, aunque actualmente se sabe que existen SRA locales o tisulares. A nivel …