Pax factors in transcription and epigenetic remodelling
A Mayran, A Pelletier, J Drouin - Seminars in Cell & Developmental Biology, 2015 - Elsevier
The nine Pax transcription factors that constitute the mammalian family of paired domain
(PD) factors play key roles in many developmental processes. As DNA binding transcription …
(PD) factors play key roles in many developmental processes. As DNA binding transcription …
Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor
Understanding brain development remains a major challenge at the heart of understanding
what makes us human. The neocortex, in evolutionary terms the newest part of the cerebral …
what makes us human. The neocortex, in evolutionary terms the newest part of the cerebral …
Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …
PAX genes in childhood oncogenesis: developmental biology gone awry?
P Mahajan, PJ Leavey, RL Galindo - Oncogene, 2015 - nature.com
Childhood solid tumors often arise from embryonal-like cells, which are distinct from the
epithelial cancers observed in adults, and etiologically can be considered as 'developmental …
epithelial cancers observed in adults, and etiologically can be considered as 'developmental …
PAX3 and FOXD3 promote CXCR4 expression in melanoma
Metastatic melanoma is an aggressive and deadly disease. The chemokine receptor
CXCR4 is active in melanoma metastasis, although the mechanism for the promotion and …
CXCR4 is active in melanoma metastasis, although the mechanism for the promotion and …
Structures and properties of PAX linked regulatory networks architecting and pacing the emergence of neuronal diversity
Over the past two decades, Pax proteins have received a lot of attention from researchers
working on the generation and assembly of neural circuits during vertebrate development …
working on the generation and assembly of neural circuits during vertebrate development …
The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function
M Tanaka-Matakatsu, J Miller, W Du - Protein & Cell, 2015 - academic.oup.com
Pax6 and its Drosophila homolog Eyeless (Ey) play essential roles during eye development.
Ey/Pax6 contains two distinct DNA binding domains, a Paired domain (PD) and a …
Ey/Pax6 contains two distinct DNA binding domains, a Paired domain (PD) and a …
The olive flounder (Paralichthys olivaceus) Pax3 homologues are highly conserved, encode multiple isoforms and show unique expression patterns
S Jiao, X Tan, Q Wang, M Li, SJ Du - Comparative Biochemistry and …, 2015 - Elsevier
Pax genes encode a highly conserved family of transcription factors that play crucial roles in
the formation of tissues and organs during development. Pax3 plays crucial roles in …
the formation of tissues and organs during development. Pax3 plays crucial roles in …
Dermestes maculatus: an intermediate-germ beetle model system for evo-devo
J Xiang, IS Forrest, L Pick - EvoDevo, 2015 - Springer
Background Understanding how genes change during evolution to direct the development
of diverse body plans is a major goal of the evo-devo field. Achieving this will require the …
of diverse body plans is a major goal of the evo-devo field. Achieving this will require the …
The RED domain of Paired is specifically required for Drosophila accessory gland maturation
The evolutionarily conserved paired domain consists of the N-terminal PAI and the C-
terminal RED domains, each containing a helix–turn–helix motif capable of binding DNA …
terminal RED domains, each containing a helix–turn–helix motif capable of binding DNA …