Protein transport into the endoplasmic reticulum (ER) is essential for all eukaryotic cells and
evolutionary related to protein transport into and across the cytoplasmic membrane of …

In mammalian cells, the rough endoplasmic reticulum or ER plays a central role in the
biogenesis of most extracellular plus many organellar proteins and in cellular calcium …

In mammalian cells, signal peptide-dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic polypeptide-conducting channel, the heterotrimeric …

The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the
generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the …

Protein translocation into the endoplasmic reticulum (ER) constitutes the first step of protein
secretion. ER protein import is essential in all eukaryotic cells and is particularly critical in …

The membranes of cells are highly complex and heterogeneous structures that fulfill multiple
vital tasks. They form thin barriers that seal out the environment, thus defining the cell's …