Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Dominant optic atrophy (DOA), and axonal peripheral neuropathy (Charcot-Marie-Tooth type
2, or CMT2) are hereditary neurodegenerative disorders most commonly caused by …

Objective Mounting evidence links neurodegenerative disorders such as Parkinson disease
and Alzheimer disease with mitochondrial dysfunction, and recent emphasis has focused on …

Mitochondrial dynamics, fission and fusion, were first identified in yeast with investigation in
heart cells beginning only in the last 5–7 years. In the ensuing time it has become evident …

Leber hereditary optic neuropathy is due to mitochondrial DNA mutations; in∼ 70% of all
cases, a point mutation in the mitochondrial NADH dehydrogenase subunit 4, ND4, gene …

We have reported previously that a missense mutation in the mitochondrial fission gene
Dynamin-related protein 1 (Drp1) underlies the Python mouse model of monogenic dilated …

Orexin A and B, orexigenic peptides produced primarily by the lateral hypothalamus that
signal through two G protein-coupled receptors, orexin receptors 1/2, have been implicated …

Mitochondrial complex I (NADH dehydrogenase) is a major contributor to neuronal
energetics, and mutations in complex I lead to vision loss. Functional, neuroanatomical and …

Sir, We have been following with great interest the developments in the field of phenotypic
diversity associated with mutations in the OPA1 gene, having contributed to describe the …

Apoptosis‐inducing factor (AIF) exerts dual roles on cell death and survival, but its
substrates as a putative oxidoreductase and roles in tumorigenesis remain elusive. Here, we …