Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

F Coll, R McNerney, MD Preston… - Genome medicine, 2015 - Springer
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

A microbiological revolution meets an ancient disease: improving the management of tuberculosis with genomics

M Wlodarska, JC Johnston, JL Gardy… - Clinical microbiology …, 2015 - Am Soc Microbiol
Tuberculosis (TB) is an ancient disease with an enormous global impact. Despite declining
global incidence, the diagnosis, phenotyping, and epidemiological investigation of TB …

Multidrug-resistant Mycobacterium tuberculosis of the Latin American mediterranean lineage, wrongly identified as mycobacterium pinnipedii (Spoligotype …

ER Dalla Costa, SEG Vasconcelos… - Journal of clinical …, 2015 - Am Soc Microbiol
We recently detected the spoligotype patterns of strains of Mycobacterium pinnipedii, a
species of the Mycobacterium tuberculosis complex, in sputum samples from nine cases …

The genomics of adaptation to mutational degradation in hypermutator Pseudomonas aeruginosa

K Heilbron - 2015 - ora.ox.ac.uk
Genetic diversity is generated and maintained even in the simplest of environments.
Because interactions between pairs of mutations are incredibly common, genetic diversity …

Multidrug-resistant Mycobacterium tuberculosis of the Latin American Mediterranean lineage, wrongly identified as Mycobacterium pinnipedii (spoligotype …

ERD Costa, SEG Vasconcelos, LS Esteves, HM Gomes… - 2015 - cabidigitallibrary.org
We recently detected the spoligotype patterns of strains of Mycobacterium pinnipedii, a
species of the Mycobacterium tuberculosis complex, in sputum samples from nine cases …

The Use of Genomics in Microbiology: From Vaccines to Drug Resistance

GA Hill-Cawthorne - 2015 - repository.kaust.edu.sa
Since 2004 sequencing has undergone a revolutionary change with the advent of first the
454 sequencer, followed by the introduction of the Solexa/Illumina chemistries. This has led …

Bioinformatic analysis of Mycobacterium tuberculosis whole genome data

CI Cerezo - 2015 - researchonline.lshtm.ac.uk
Tuberculosis (TB) caused by bacteria of the Mycobacterium-tuberculosis complex (MTBC) is
the second major cause of death from an infectious disease worldwide. Recent advances in …