Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …

Clostridium difficile is well recognized as the leading cause of antibiotic-associated diarrhea,
having a significant impact in both health-care and community settings. Central to …

Recombination is an important evolutionary force in bacteria, but it remains challenging to
reconstruct the imports that occurred in the ancestry of a genomic sample. Here we present …

Clostridium difficile infection remains a major healthcare burden. Until the recent
introduction of fidaxomicin, antimicrobial treatments were limited to metronidazole and …

The major virulence factors of Clostridium difficile are toxins A and B. These toxins are
encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with …

Two linezolid-resistant Enterococcus faecium isolates (MICs, 8 μg/ml) from unique patients
of a medical center in New Orleans were included in this study. Isolates were initially …

Premature infants are highly vulnerable to aberrant gastrointestinal tract colonization, a
process that may lead to diseases like necrotizing enterocolitis. Thus, spread of potential …

Clostridium difficile is the cause of most frequently occurring nosocomial diarrhea
worldwide. As an enteropathogen, C. difficile must be exposed to multiple exogenous …

We studied the molecular mechanisms of linezolid resistance in 9 isolates of toxigenic
Clostridium difficile with high linezolid MICs. The activity of linezolid was determined against …

Approaches to exploring Clostridium difficile genomic diversity have ranged from molecular
typing methods to use of comparative genome microarrays and whole genome sequence …